There is not enough evidence in the literature to recommend a specific adjunctive medication at this time. In this area, too, more studies are needed, as there are no drugs currently approved to treat benzodiazepine withdrawal. Off label, very small studies (less than 40 patients) and case reports have shown that drugs such as gabapentin, carbamazepine, and propranolol may help as aids in withdrawal. Trazodone, mirtazapine, and quetiapine may be helpful in some patients for insomnia. But not everyone finds them helpful; they must be tapered off; and they carry the potential of causing their own withdrawal syndrome. Some patients have reported relief of withdrawal symptoms with the use of CBD oil or medical marijuana. Many patients are able to successfully complete a taper without the use of adjunctive medication.
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